2011 Lect 15 Hardy Weinberg population genetics

2011 Lect 15 Hardy Weinberg population genetics -...

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From genes to populations
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om individuals to populations From individuals to populations e know alleles are randomly distributed into We know : alleles are randomly distributed into gametes within individuals How are alleles distributed in a population? from Mendel to population genetics
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Hardy Weinberg: random sortment of alleles in populations assortment of alleles in populations
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What is a population? A group of individuals that can interbreed Living in the same place at the same time R. Hicker: spawning Capelin
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Moving from single crosses to populations hen 2 heterozygous individuals mate they When 2 heterozygous individuals mate, they each make a pool of gametes, which ssentially pair up randomly essentially pair up randomly We will assume the same thing happens within populations art y crossing a ith a Start by crossing Aa with Aa
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Aa x Aa Genotypic frequencies: .25 AA .5 Aa .25 aa a A .5 .5 Chance of getting AA? (freq A) * (freq A) = .25 Aa AA A a = 2 (freq A) * (freq a) = .5 a Aa .5 .25 .25 Aa? 2 (freq A) (freq a) .5 aa a a .5 .25 .25 Assign freq A = p And freq a = q
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Hardy Weinberg: allele and genotype frequencies Alleles : p = freq A, q = freq a a A p + q must = 1 Genotypes : A p q Aa AA Freq AA = p x p = p 2 Freq aa = q 2 p a a p 2 pq Freq Aa = (pq) x 2 p 2 + 2pq + q 2 = 1 a q aa Aa q 2 pq
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e can think of a randomly mating population We can think of a randomly mating population as a collection of randomly assorting alleles: is is powerful e can use the same This is powerful—we can use the same principles for populations that we were using r individuals for individuals Population genetics
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2011 Lect 15 Hardy Weinberg population genetics -...

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