Lecture_2-_Stem_cells_and_disease

Lecture_2-_Stem_cells_and_disease - Building novel...

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Building novel neurological disease models using human embryonic stem cell-derived neurons Yi E. Sun UCLA
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Stem Cell Applications Building disease models for drug development Cell replacement therapies This is the more obvious view of the use of stem cells: re‐introduce missing cells back into the compromised tissues. This is the less obvious (but equally important) use for stem cells: Recreate human diseased tissues to study in controlled environments.
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Stem Cells
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These cells are specialized to provide an indefinite supply of fresh, differentiated cells: Stem Cells Taken from: . Molecular Biology of the Cell, 5 th Edition. (2008). Garland Science. Pg 1420. Note that: 1) One cell is differentiated while the other cell remains undifferentiated. 2) The stem cell can divide indefinitely.
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Stem cells not only produce every tissue during development (embryonic stem cells)… Stem Cells …but also regenerate some tissues after development (adult stem cells). Image taken from: http://www.eurostemcell.org/files/images/Human-blastocyst.gif Image taken from: http://www.siteman.wustl.edu/xmlfiles/Media_big/ CDR0000526538.jpg
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Stem cells are divided based on their potential to develop different cell types: Stem Cells Only embryonic tissues Multipotent Image taken from: http://www.patentbaristas.com/wp/ wp-content/uploads/2007/04/stem-cells.jpg
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There are two ways for a stem cell to determine its fate: Stem Cells Taken from:
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This note was uploaded on 04/19/2011 for the course LS 2 taught by Professor Pires during the Spring '08 term at UCLA.

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Lecture_2-_Stem_cells_and_disease - Building novel...

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