PHL 344 Final Study Guide COMPLETED

PHL 344 Final Study Guide COMPLETED -...

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Know the definitions of these terms; know what the debate it about  Triage A system for sorting people into groups based on their need or ability to  benefit from treatment. Randomized  The process of assigning subjects in a research experiment to a treatment or  control group by chance Clinical trial Trails designed to test the safety and efficacy of drugsn or procedures, prior  to their being approved for use. Tuskegee syphilis study  A medical experiment conducted by the U.S. Public Health Service from the  1930s to the 1970s. It studied the course of syphilis in about 400 poor black  men in Alabama. IN 1997, President Bill Clinton apologized to the survivors  and their families for the U.S. Government having aced in a “morally wrong”  way. They were told that they had syphilis; they were told that they were being  “treated” for “bad blood”. In fact, they were offered no treatment; their disease  was left to run its course even though there were treatments for syphilis  available. The men were not told they were part of a research study.  Phase I trial   trials take place in “phases” and each phase of a clinical trial has a different  purpose and aims to answer a different question. Phase 1 trials involve a  small group of subjects and aim to test the safety of the drug or treatment and  identify side effects.  not intended as therapeutic  o the point is research (generalizable knowledge)  o the probability of benefit is a small amount
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Placebo   a biologically inert pill or substance Interim data trends or results you have seen in earlier parts of the trial Double-blind  An experimental study in which neither the researcher nor the subject knows  to which control or treatment group the subject is assigned. IRB (institutional review board) The committee at universities and medical institutions that is responsible for  protecting human subjects of research (reviewing and approving research  protocols and upholding federal guidelines). Belmont Report The 1979 report of the U.S. National Commission for the Protection of Human  Subjects of Biomedical and Behavioral Research. It presents the principles of  autonomy, beneficence and justice as necessary to ethical research. Nuremberg Code A code of ethics for medical research drawn up after the Nazi medical  experiments during World War II. Nazi doctors were prosecuted for war crimes and crimes against humanity, 
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This note was uploaded on 04/20/2011 for the course PHL 344 taught by Professor Staff during the Fall '08 term at Michigan State University.

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PHL 344 Final Study Guide COMPLETED -...

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