dna - the double helix shape James Watson and Francis Crick...

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DNA.notebook April 11, 2011 Evidence for DNA Was genetic information carried in DNA or Proteins? 3 major studies proved that DNA existed 1928 Frederick Griffith studies of Streptococcus pneumoniae 1944 Oswald Avery studies the macromolecules in the mice from Griffith's studies 1952 Alred Hershey and Marth Chase study radioactive labelled bacteriophages 1920's Nucleotides discovered P.A. Levene determined the basic structure of a nucleotide ­5 Carbon sugar (deoxyribose ­or­ ribose) ­Phosphate group ­Nitrogen Base Adenine Thymine Cytosine Guanine 1950 Erwin Chargaff analyzes the amount of nitrogne bases in living cells Chargaff's Rule: Adenine bonds with Thymine and Cytosine bonds with Guanine DNA RNA
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DNA.notebook April 11, 2011 DNA Structure 1951 Rosalind Franklin takes "Photo 51" showing
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Unformatted text preview: the double helix shape James Watson and Francis Crick see the photo and use Chargaff's Rule to assemble a DNA model Two outside strands of alternating deoxyribose and phosphate Cytosine pairs with Guanine through a triple bond Adenine pairs with Thymine through a double bond Published 1page letter in "Nature" in 1953. DNA Structure A = T & G = C Therefore A + G = C + T If we know that there a person's DNA is 32% Thymine can we figure out the rest? DNA Orientation The Carbons on the deoxyribose sugar are numbered The two strands of DNA run opposite each other One strand goes 5' to 3' while the other goes 3' to 5' This orientation is called "antiparallel"...
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This note was uploaded on 04/22/2011 for the course BIO 101 taught by Professor Truny during the Fall '09 term at Grand Valley State University.

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dna - the double helix shape James Watson and Francis Crick...

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