o Adhesive molecules: most normal cells will not grow unless they are adherent (cancer cells lose this restriction) Fibronectin: binds cells to the matrix and help guide cell movement, soluble and insoluble forms, contains binding sites both for cell surface receptors and several extracellular components [Heparin (a GAG and anticoagulant), fibrin (blood clotting protein), collagen], found nearly everywhere, including the blood where it helps bind platelets to blood clots Laminin: another “bridging” molecule, for attaching cells to matrix components, found more-or-less exclusively in basal laminae binding sites for cell surface receptors, heparin and heparin sulfate, type IV collagen, entactin • Basil lamina: Thin sheet of specialized extracellular matrix that covers some cells, structural support, transport barrier, phenotypic regulation, contains proteoglycans, type IV collagen, fibronectin, laminin Adhesion receptors: r eceptors for proteins or carbohydrates that serve primarily a
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.