Blood Cell Types

Blood Cell Types - organisms, recruit additional white...

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Leukocytes: white blood cells, primary mediators of immune response Transmigration: process of pushing through blood vessel wall into tissue Granulocytes (polymorphonucleocytes): multilobed nuclei o Neutrophils: phagocytosis, chemical attack on bacteria and other foreign objects o Basophils/mast cells: leave the tissue to become mast cells, release substances that increase vascular permeability and recruit other immune cells – inflammation, highly granular, can degranulate, release pro-inflammatory substances which recruit more white cells (“homing”) and increase vascular permeability o Eosinophils: generally involved in attacks on parasites and multicellular organisms, distinct Golgi, distinctive granules, normally few in the circulation, attack parasites, synthetic (will regenerate their secretory granules), granule components are toxic to eukaryotic, multicellular
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Unformatted text preview: organisms, recruit additional white blood cells (cytokines, including interleukins) Cytokines: small proteins that pass signals between immune cells Chemokines: a simple compound produced by one cell that effects the activity of another, more generic term than cytokines Lipoxygenase: enzyme which catalyzed arachidonic acid to leukotrienes Leukotrienes: chemokines derived from arachidonic acid through the action of the enzyme lipoxygenase, increase vascular permeability, giving rise to edema, cause bronchioles to constrict due to smooth muscle contraction, cause mucus secretion by respiratory epithelial cells, promote white cell homing, eosinophils in particular Interleukins : cytokines involved in regulation of immune function...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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