Cystic Fibrosis and Membrane Transport

Cystic Fibrosis and Membrane Transport - surfaces),...

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Cystic Fibrosis and Membrane Transport Active transport: transport across the cell membrane which require energy o Primary active transport: energy from ATP hydrolysis is used directly by the transporter to move a substance (see above chart) Na+/K+ ATPase: e xchanges three sodium ions OUT and two potassium ions IN utilizing one ATP, most important transporter you have, gradients are used in secondary active transport to move all sorts of other things, central to maintaining the membrane potential F 1 ATPase: driven by proton flow, functions as an ATP generator, “spoke” turns in 120º steps within six surrounding subunits, deforming them., three corresponding sites of ATP synthesis / hydrolysis o Secondary active transport: energy from an electrochemical gradient is used to drive the transport of another substance o Cotransporter: use one transport to drive the other, ions provide energy o Amphipathic molecules: love/hate relationship with water Tight junction: diffusion barrier between cells, segregates the membranes (apical vs. baso-lateral
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Unformatted text preview: surfaces), provides for directional and regulated transport o Apical: surface of the plasma membrane that faces the lumen Lumen: inside space of a tubular structure, such as an artery or intestine. [1] By extension, a lumen can also be the inside space of a cellular component or structure (inner membrane) o Basolateral: surface of the plasma membrane that forms its basal and lateral surfaces. It faces towards the interstitium, and away from the lumen Interstitium: solution that bathes and surrounds the cells of multicellular animals (outer membrane) Cystic Fibrosis Transconductance Regulator (CFTR): member of the ABC superfamily of transport proteins, does not appear to act as an active transporter - chloride channel facilitated diffusion, activated by phosphorylation , permits chloride movement to the epithelial surface - results in osmotic flux of water to the apical surface, diluting mucus, when broken, CF...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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