Extracellular matrix

Extracellular matrix - Ligaments: connects bone to bone...

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Extracellular matrix: (connective tissue, interstitium) collection of proteins and carbohydrates produced by cells that forms a matrix outside cells, and in which cells live. It’s like a cellular nest, involved in disease processes, including atherosclerosis, cancer, arthritis, lupus, influences cell behavior and gene expression, essentially a gel (fibrous solid with a viscous fluid between) created by and adhered to cells o Structural fibers: c onfer stiffness and rigidity to otherwise-fluid biological components Collagens: Formed of parallel fibrils, high modulus of elasticity, many types (e.g. type I), major constituent of tendons, fibrils are further stabilized and strengthened by cross- links between lysines (catalyzed by the enzyme lysyl oxidase, a copper-dependent enzyme) Tendons: connect muscle to bone Elastin: an amorphous protein, much lower modulus of elasticity than collagen, primary constituent of many ligaments, crosslinked tropoelastin, entropic spring
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Unformatted text preview: Ligaments: connects bone to bone Modulus of elasticity: mathematical description of an object or substance's tendency to be deformed elastically, high modulus of elasticity stiff o Hydrated matrix: viscous fluid which surrounds cells Extracellular fluid: what cells live in and like, nearly isosmotic (isotonic) with the cytoplasm, low in protein, bicarbonate buffered, sodium and chloride are the major ions Saline: 0.9% NaCl Ringer-Lactate: (Hartmanns) provides sodium, calcium, chloride and bicarbonate in concentrations similar to those of the human body Protoglycans : complex of a core protein and glycosaminoglycans, GAGs are linear, repeating disaccharides with amine modifications, often sulfated, always negative, the hydrophilic GAGs spring away from one another, and form a hydrated matrix, reduce hydraulic conductivity, resist compression, bind cations, bind growth factors...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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