{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Extracellular matrix

Extracellular matrix - • Ligaments connects bone to bone...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Extracellular matrix: (connective tissue, interstitium) collection of proteins and carbohydrates produced by cells that forms a matrix outside cells, and in which cells live. It’s like a cellular nest, involved in disease processes, including atherosclerosis, cancer, arthritis, lupus, influences cell behavior and gene expression, essentially a gel (fibrous solid with a viscous fluid between) created by and adhered to cells o Structural fibers: c onfer stiffness and rigidity to otherwise-fluid biological components Collagens: Formed of parallel fibrils, high modulus of elasticity, many types (e.g. type I), major constituent of tendons, fibrils are further stabilized and strengthened by cross- links between lysines (catalyzed by the enzyme lysyl oxidase, a copper-dependent enzyme) Tendons: connect muscle to bone Elastin: an amorphous protein, much lower modulus of elasticity than collagen, primary constituent of many ligaments, crosslinked tropoelastin, entropic spring
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: • Ligaments: connects bone to bone Modulus of elasticity: mathematical description of an object or substance's tendency to be deformed elastically, high modulus of elasticity – stiff o Hydrated matrix: viscous fluid which surrounds cells Extracellular fluid: what cells “live in” and “like”, nearly isosmotic (isotonic) with the cytoplasm, low in protein, bicarbonate buffered, sodium and chloride are the major ions • Saline: 0.9% NaCl • Ringer-Lactate: (Hartmann’s) provides sodium, calcium, chloride and bicarbonate in concentrations similar to those of the human body Protoglycans : complex of a “core protein” and glycosaminoglycans, GAGs are linear, repeating disaccharides with amine modifications, often sulfated, always negative, the hydrophilic GAGs spring away from one another, and form a hydrated matrix, reduce hydraulic conductivity, resist compression, bind cations, bind growth factors...
View Full Document

{[ snackBarMessage ]}