The Molecular Motor

The Molecular Motor - o Peroxynitrite: formed through...

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Molecular motor: consist of motor domains and cargo-binding domains o Motor domain: head of molecular motor o Cargo-binding domain: tail of molecular motor o Kinesins : mostly plus directed o Dyneins : minus directed, two types – cytoplasmic and axonemal Cytoplasmic : cargo transport Axonemal : ciliary and flagellar motion Microtubule organizing centers (MTOCs): location at which microtubules are nucleated, contain microtubule structures that form stable (-) ends for growing microtubules, contain - γ tubulin which may stabilize these nascent microtubules o Centrosome : example of an MTOC Fasciculation : involuntary muscle twitch, usually localised and temporary Sporatic : unknown origin Familial : origin identified in genes o Superoxide dismutase: gene in which mutations are known to cause familial ALS, enzyme which catalyzes reaction changing superoxide to peroxide o Superoxide: normal though harmful byproduct of oxidative metabolism o Peroxide: also harmful but more easily dealt with
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Unformatted text preview: o Peroxynitrite: formed through excess superoxide, very reactive ion, but not a free radical • Motor neurons: neurons that connect with muscles and direct movements • Axonal transport: cellular process responsible for movement of mitochondria, lipids, synaptic vesicles, proteins, and other cell parts (i.e. organelles) to and from a neuron's cell body, through the cytoplasm of its axon • Chemotherapeutic: therapy through the use of chemical agents o Antimiotics: drugs which prevent mitosis (cell division) o Taxol: stabilizes microtubules, blocking complete cell division • Colchicine: causes disassembly of microtubules o Polyploid: twice the haploid number of chromosomes o Overexpression: artificial expression of a gene in increased quantity • Phallotoxin (phalloidin): an actin filament stabilizer, the poison in some mushroom genera, kills by stabilizing actin filaments (inhibiting disassembly), death is liver failure...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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The Molecular Motor - o Peroxynitrite: formed through...

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