Alcohol - of acetaldehyde adducts yielding neoantigens,...

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Alcohol Alcohol: oxidized to acetaldehyde by “reverse” action of alcohol dehydrogenase using NAD + o Acetaldehyde: may be metabolized to acetyl CoA by acetaldehyde dehydrogenase using another NAD + , which is required for β-oxidation of fats, and if depleted prevents fat breakdown; not a normal product in animal cells (toxic - causes mitochondrial failure, increasing generation of free radicals, depletion of anti-oxidants, like glutathione, formation
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Unformatted text preview: of acetaldehyde adducts yielding neoantigens, triggers collagen secretion) o Alcohol dehydrogenase: enzyme which catalyzes oxidation of alcohol to acetaldehyde o Acetaldehyde dehydrogenase: enzyme which catalyzes reaction of acetaldehyde to form acetyl CoA o Acetyl CoA: raw material for synthesis of fat • Cirrhosis: accumulation of fat in hepatocytes, death of cells, immune attack and synthesis of collagen...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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