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Antibody - o Immune complexes multivalent antibodies(can...

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Antibody: y-shaped molecule; antigen binding domains (variable domains, Fab’s) and the leg (constant domains, Fc); tetrapeptide – two identical light chains + two identical heavy chains; portions of both are variable and constant; binds to an antigen, and helps dispose of it; cell bound or secreted o Secreted: can stick to cells by Fc receptors o Bound: sometimes synthesized with a hydrophobic transmembrane domain on Fc Alpha helices: sometimes used across lipid bilayers; integral transmembrane proteins contain one or more transmembrane helices; non polar side groups face outwards towards the fatty acid tails, leaving the polar backbone protected o Hydropathy (hydrophobicity) plot: a plot of the average hydrophobicity of amino acids versus their position in the primary structure
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Unformatted text preview: o Immune complexes: multivalent antibodies (can bind multiple antigens), can cross-link antigens; facilitates phagocytosis, degranulation of granulocytes, activation of the complement system Immunoprecipitation: antibodies cross-linked with antigen can form a precipitate o Antibody classes: IgX, where Ig stands for immunoglobin IgG: the bulk of secreted antibody, against blood-borne antigens; as much as 20% of serum protein IgD: another antigen receptor on B cells IgM: antigen receptor on B cell surface, and the first class generated in an immune response, much larger than IgG IgA: against mucosal (epithelial) antigens IgE: bind to mast cells, and trigger degranulation and the classic “allergic reaction”...
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