B cells - stem cells give rise to many millions of...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
o B cells: create antibodies, humoral immunity, secrete antibodies into blood stream; ingest, digest and display parts of antigens: antigen display or antigen presentation; antigen receptors are membrane bound immunoglobulins (Ig, aka antibodies), which can bind free antigens; activate when antigen binds to surface Ig, activated in combination with cytokines from T cells Antigen display/presentation: Antigen receptors: recognizes a small number of structurally related epitopes (lock and key mechanism), once differentiated, each cell is committed to producing only one specific antigen receptor forever (one lymphocyte per epitope), though you need many lymphocytes to produce the huge variety of antibodies needed for diversity Antigen-independent differentiation:
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: stem cells give rise to many millions of different antigenically-commited lymphocytes; each only produces one specific antigen receptor, generated at random; happens before birth in the primary lymphoid tissues and does not require the presence of an antigen Antigen-dependent differentiation: clonal selection; only those lymphocytes whose receptor recognizes the antigen become activated, and then proliferate; once an antigen binds to an antigenically-committed cell, that cell divides, producing many fully active effector cells • Plasma cells: effector cells for B cells, manufacture antibodies in large quantities • Memory cells: long-lived for a secondary response, provide for an enhanced secondary immune response to a previously encountered antigen...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern