B cells - stem cells give rise to many millions of...

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o B cells: create antibodies, humoral immunity, secrete antibodies into blood stream; ingest, digest and display parts of antigens: antigen display or antigen presentation; antigen receptors are membrane bound immunoglobulins (Ig, aka antibodies), which can bind free antigens; activate when antigen binds to surface Ig, activated in combination with cytokines from T cells Antigen display/presentation: Antigen receptors: recognizes a small number of structurally related epitopes (lock and key mechanism), once differentiated, each cell is committed to producing only one specific antigen receptor forever (one lymphocyte per epitope), though you need many lymphocytes to produce the huge variety of antibodies needed for diversity Antigen-independent differentiation:
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Unformatted text preview: stem cells give rise to many millions of different antigenically-commited lymphocytes; each only produces one specific antigen receptor, generated at random; happens before birth in the primary lymphoid tissues and does not require the presence of an antigen Antigen-dependent differentiation: clonal selection; only those lymphocytes whose receptor recognizes the antigen become activated, and then proliferate; once an antigen binds to an antigenically-committed cell, that cell divides, producing many fully active effector cells • Plasma cells: effector cells for B cells, manufacture antibodies in large quantities • Memory cells: long-lived for a secondary response, provide for an enhanced secondary immune response to a previously encountered antigen...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

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