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Cellular basis of immunity

Cellular basis of immunity - Cellular basis of immunity...

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Cellular basis of immunity: Celiac disease and transplant rejection Innate immunity: pre-programmed antigen recognition; receptors which are pre-designed to bind to molecules common to microorganisms o Scavenger and mannose receptors: bind to sugars on bacteria o LPS (lipopolysaccharide): molecule only found on some bacteria o Toll receptors (and toll-like receptors, TLRs): help discriminate between types of pathogens Non-lymphocyte white cells: activated when antibodies bind to antigens; these complexes bind to Fc receptors on many immune cells (mostly granulocytes), which are activated, causing degranulation and phagocytosis T cell receptors: also called TCRs, are also immunoglobins; bind specific epitopes, exist with incredible variety in their variable domains, each T cell makes only one version, membrane proteins; used by T cells to recognize antigens, as antibodies are used by B cells; only bind antigen when presented by a MHC Major histocompatibility complex:
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  • Spring '11
  • Kim
  • Cytotoxic T cells, Transplant Rejection, cells Exogenous pathway, Non-lymphocyte white cells, pre-programmed antigen recognition

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