Cellular basis of immunity

Cellular basis of immunity - Cellular basis of immunity:...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Cellular basis of immunity: Celiac disease and transplant rejection Innate immunity: pre-programmed antigen recognition; receptors which are pre-designed to bind to molecules common to microorganisms o Scavenger and mannose receptors: bind to sugars on bacteria o LPS (lipopolysaccharide): molecule only found on some bacteria o Toll receptors (and toll-like receptors, TLRs): help discriminate between types of pathogens Non-lymphocyte white cells: activated when antibodies bind to antigens; these complexes bind to Fc receptors on many immune cells (mostly granulocytes), which are activated, causing degranulation and phagocytosis T cell receptors: also called TCRs, are also immunoglobins; bind specific epitopes, exist with incredible variety in their variable domains, each T cell makes only one version, membrane proteins; used by T cells to recognize antigens, as antibodies are used by B cells; only bind antigen when presented by a MHC Major histocompatibility complex: also called MHC or HLA (human leukocyte antigen);
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.
Ask a homework question - tutors are online