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Unformatted text preview: organelle membranes Nitric oxide: free radical, gas, diffusible signaling molecule for both intra cellular and inter cellular signaling, synthesized from arginine by nitric oxide synthases; activates a protein kinase, which itself regulates proteins; regulates proteins directly, which have various roles around the body (vasodilation, killing of bacteria by immune cells, terminates free radical chain reactions); function in neurons isnt always clear (some parasympathetic nerves generate it as a neurotransmitter, important for motor neuron survival, but how and why?, control of excitability) NO + O2- : fastest known reaction in chemistry; both can be produced in large quantities in pathologic conditions, producing peroxynitrite (ONOO-) o Peroxynitrite (ONOO-): in the presence of CO 2 , ONOO-reacts with proteins, often leading to necrosis or apoptosis Necrosis: Apoptosis:...
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This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.
- Spring '11