Tricarboxylic acid

Tricarboxylic acid - Aerobic: in the presence of O2,...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Aerobic: in the presence of O2, substrates are oxidized to CO2 and H2O; some tissues operate under both conditions, occurs in the mitochondrion in eukaryotes, two major steps: tricarboxylic acid (Kreb’s/citric acid cycle) and oxidative phosphorylation; takes place in the mitochondria o Coenzymes: intermediate electron acceptors/donors (oxygen is the final electron acceptor, but electrons are not normally passed directly to oxygen), function along with enzymes as substrates but are not consumed Nicotinamide adenine dinucleotide (NAD + ): most common coenzyme ; NAD + + H + + 2 e - ↔ NADH ; NAD + + 2[H] ↔ NADH + H + ; electrons “stored” this way represent potential energy Flavin adenine dinucleotide (FAD): another common coenzyme ; same idea as with NAD+ o Tricarboxylic acid (TCA) cycle (a.k.a. Krebs cycle, citric acid cycle): generates NADH, entry point for amino acids into metabolism, generates NADH and another reduced coenzyme, FADH 2 , consumes water and yields CO
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/23/2011 for the course BIME 2102 taught by Professor Kim during the Spring '11 term at UVA.

Ask a homework question - tutors are online