TRVPA1 - stimulus which could prove harmful is acting upon...

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The idea of using a caustic substance on an open wound seems radical and perhaps irrational at first. After all, it is not common for someone to intentionally cause themselves mild to severe discomfort. However, it is much less addicting than more common analgesics such as morphine or oxycodine. Pain is caused when nerve endings experience intense stimuli such as extreme heat, cold, or pressure (Glynn 121). Various types of nerve endings react to different types of pain; on one hand, sharp, short, pains, such as those experienced when one unintentionally burns or cuts oneself, are small fibers which react quickly to the situation (Glynn 121). On the other hand, larger fibers which react more slowly are associated with persistence, duller pains such as those experienced in an ache or cramp (Glynn 122). The latter of these two sensory cells has a receptor which is called the vanilloid receptor subtype 1, or TRPV1, for short. TRPV1 is a nociceptor in that it sends a signal to the brain indicating that a
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Unformatted text preview: stimulus which could prove harmful is acting upon the body (Binshtok 1). This signal can be blocked through the use of sodium blockers, which bond to the nerve ending. This is achieved through the use of the capsaicin compound, which binds to TRPV1 and causes the relief from the pain (China View 1). However, one may inquire as to what happens to the uncomfortable pain caused by the spiciness of the pepper. C neurons are common receptors sensitive to heat. Is it not true that these nerves will sense the capsaicin stimulus? The opening of the TRPV1 receptor, however, causes a release of excess calcium, which overloads the C cells, and causes them to shut down, thus making them invulnerable to the pepper’s heat. This causes a numbness in the area. With continued research, it is not impossible that this technique could be utilized in various areas of modern medicine....
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TRVPA1 - stimulus which could prove harmful is acting upon...

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