lecture27_single_molecules

lecture27_single_molecules - k B → A t Drive system out...

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A B k A B k B A Protein folding d [ A ] / dt = - k A B [ A ] + k B A [ B ] d [ B ] / dt = k A B [ A ] - k B A [ B ] time Signal, e.g.~[A] ~ exp - ( k A B + k B A ) t Drive system out of equilibrium by rapid mixing, T-jump etc.
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Single-molecule fluorescence resonance energy transfer (FRET)
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Chemical kinetics with single molecules A B time B A t A t B k A B k B A signal (e.g., fluorescence) time Signal ~ exp - ( k A B +
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Unformatted text preview: k B → A ) t Drive system out of equilibrium (i.e., synchronize molecules ) by rapid mixing, T-jump etc. SINGLE MOLECULE EXPERIMENT BULK EXPERIMENT time B A t A t B signal (e.g., fluorescence) p ( t A ) = k A → B exp(-k A → B t A ) t A , B = 1/ k A → B...
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lecture27_single_molecules - k B → A t Drive system out...

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