310-19 - Organic Lecture Series CH 310 N LECTURE 19...

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Organic Lecture Series 1 CH 310 N LECTURE 19 Textbook Assignment: Chap 18 begin Homework (for credit): POW 6 posted (Due Mar 7) Today’s Topics: Nucleophilic Acyl Substitution Reactions Notice & Announcements: Exam 1-grades posted to BB Organic Lecture Series 2 Functional Functional Derivatives of Derivatives of Carboxylic Acids Carboxylic Acids
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Organic Lecture Series 3 Nucleophilic Nucleophilic acyl acyl substitution: substitution: an addition-elimination sequence resulting in substitution of one nucleophile for another Tetrahedral carbonyl addition intermediate - + + C Nu R C Y R C R O Y O O :Nu - :Y - Substitution product : Characteristic Reactions Characteristic Reactions Organic Lecture Series 4 + (cat) Fischer Fischer Esterifications Esterifications
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Organic Lecture Series 5 in the general reaction, the leaving group, as an anion, illustrates an important point: the weaker the base, the better the leaving group R 2 N - RO - O RCO - X - Increasing basicity Increasing leaving ability Characteristic Reactions Characteristic Reactions Organic Lecture Series 6
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This note was uploaded on 04/24/2011 for the course CH 56255 taught by Professor Colapret during the Spring '11 term at University of Texas.

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310-19 - Organic Lecture Series CH 310 N LECTURE 19...

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