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310-32 - CH 310 N LECTURE 32 Textbook Assignment Chap 22...

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1 CH 310 N LECTURE 32 Textbook Assignment: Chap 22 Rxns of Benzene & Derivatives Homework (for credit): POW 10 posted (Due Apr 11) Today’s Topics: EAS continued-Disubstitution; directing effects Notice & Announcements: “Plastic Surgery” William C. Pederson, MD - Hand Surgeon 2 EAS: General Mechanism EAS: General Mechanism A general mechanism Key question: What is the electrophile and how is it generated? + E + H E H + slow, rate determining Step 1: Step 2: E H + fast + H + E Electro- phile Resonance-stabilized cation intermediate
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