310-35&36 - Organic Lecture Series CH 310 N LECTURE...

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Organic Lecture Series 1 CH 310 N LECTURE 35 Textbook Assignment: Chapter 23 Homework (for credit): POW 11 posted (Due April 18) Today’s Topics: Basicity, reactions Notice & Announcements: Perspectives on Medicine Valerie Espinosa, MD - Endocrinology Kenneth Perret, MD - Critical Care Pulmonology Paul Tucker, MD - Interventional Cardiology Organic Lecture Series 2 Amines Amines Epinephrine (adrenaline)
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Organic Lecture Series 3 Reaction with Acids Reaction with Acids • All amines, whether soluble or insoluble in water, react quantitatively with strong acids to form water-soluble salts HO NH 2 OH HCl H 2 O 3 + Cl - ( R )-Norepinephrine hydrochloride (a water-soluble salt) + ( R )-Norepinephrine (only slightly soluble in water) Organic Lecture Series 4 Preparation Preparation • A summary of synthetic methods: – nucleophilic ring opening of epoxides by ammonia and amines (11.9B) – addition of nitrogen nucleophiles to aldehydes and ketones to form imines (Section 16.8) – reduction of imines to amines (16.8A) – reduction of amides by LiAlH 4 (18.10B) – reduction of nitriles to a 1° amine (18.10C) – nitration of arenes followed by reduction of the NO 2 group to 1° amines (22.1B)
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Organic Lecture Series 5
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310-35&36 - Organic Lecture Series CH 310 N LECTURE...

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