lecture5 - steroids 2.Masculinizing and Feminizing hormones...

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Hormones Chemical substances - produced by endocrine glands - secreted into the blood - circulate throughout the entire body. - target tissues respond to hormones.
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Target tissues
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Hormones you are responsible for: Sex Hormones – Produced by the gonads : Androgens: Testosterone, Androstenedione, DHT, Androstenediol Estrogens: Estradiol, Estrone Progesterone Gonadotropins – Produced by the pituitary: Luteninizing Hormone (LH) Follicle Stimulating Hormone (FSH) Gonadotropin Releasing Hormone (GnRH) – Produced by the hypothalamus
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Steroid Biosynthetic Pathway Pregnenolone Progesterone 17-OH Pro .. Androsteno- dione Testosterone Androsteno- dio l Dehydro… 17-Preg …. Cortiso…l Corticosterone Estradio l Estrone 11-Deoxy .. Deoxy…. Aldosterone 17-OH Cort Cholesterol 21-OH 11-OH Aromatase Aromatase 21-OH 11-OH 3B-HSO 3B-HSO 3B-HSO 3B-HSO CYP-17 CYP-17 CYP-17 Lyase Lyase 17B-HSO 17B-HSO
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What you need to know about the Steroid Biosynthetic Pathway 1.Cholesterol is the precursor to the all of the
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Unformatted text preview: steroids. 2.Masculinizing and Feminizing hormones utilize the same biosynthetic pathway. No step in the pathway can be skipped. 3.Masculinizing and Feminizing hormones are very similar in size and chemical composition. 4.The main difference is that estrogens have aromatic rings. Testosterone Testosterone at Puberty Estrogen at Puberty Negative Feedback System Testes (Interstitial Cells Produce Testosterone) LH Testosterone Hypothalamus - Thermostat Pituitary Gland – Produces LH Negative Feedback System Testes (Sertoli cells regulate sperm production) FSH Sperm Hypothalamus - Thermostat Pituitary Gland – Produces FSH Ejaculation Negative Feedback System Testes (Sertoli cells produce Inhibin) Stops FSH Inhibin – No sperm produced Hypothalamus - Thermostat Pituitary Gland – Produces FSH...
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