Lecture 26

Lecture 26 - Final Lecture 26 Post Cannabis Debate +...

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Unformatted text preview: Final Lecture 26 Post Cannabis Debate + Wrap-up What issues need to be considered regarding the legalization of pot? A little learning is a dangerous thing; drink deep, or taste not the Pierian spring: there shallow draughts intoxicate the brain, and drinking largely sobers us again. Alexander Pope Why is it dangerous because it can cause you to think that you know more than you actually do...simply cuz u dont know it completely and therefore you mostly assume the rest of it which may or may not be correct but it is not for sure, accurate or confirmed in any manner...so little knowledge is truly a very dangerous thing. hope that's satisfying... Anonymous, The Internet Graduate Studies in Psychiatry ? Check out the M.Sc. program on the Web http://www.medicine.mcgill.ca/psychiatry/ 2011 PSYT301 Votes Pro/Con Pot Legalization Pro - 12 Con - 10 Undecided - 9 What standards should we apply in deciding whether any drug should be legally available to those over the age of 18? What do we need to know? DRUG XXX Factors to consider regarding legalization: 1) Abuse liability ? Pharmacokinetics (lipid solubility, rate of onset, active metabolites, duration of action) ? Pharmacological effects (effects on mood, anxiety, euphoria, is it an intoxicant) ? Typical routes of administration (smoked, injected) ? Does it reinforce self-administration in an animal model? Does it show resistance to extinction, or reinstatement in a relapse model? What are the effects on the dopamine system ? Does it induce tolerance and physical dependence ? Drug XXX continued Prevalence of use and abuse in humans ? Pattern and route of self-administration in humans (daily use, Who uses it and for how long) ? Does a pattern of compulsive drug use develop in some users? 2) Toxicology ? (Pathophysiology) Consider acute and chronic effects. List those that are probable (following daily heavy use) vs possible long- term consequences Effects on major organ systems (i.e. brain, lungs) ? Effects on cognitive and psychomotor functioning ? Effects on daily functioning and social relations? Effects on fetal and adolescent development (teratogenic and toxic effects) ? Post-debate Conclusions: There are many possible adverse effects of cannabis that have been detailed in the scientific literature: Acute Effects - cognitive impairment, attention and memory deficits, increased psychological symptoms in vulnerable individuals (anxiety, paranoia) and psychomotor impairment Chronic Effects (daily heavy use) cannabis dependence (Swift et al. (2001) reported that 1/3 of regular cannabis users received a DSM-IV diagnosis of either substance abuse (10.7%) or dependence (21%) (n=10,641) ) possible increased risk for respiratory problems, cognitive and memory problems Consequences of THC Accumulation: In the UK, USA, Australia, and New Zealand cannabis is the most common drug (besides alcohol) to be detected in drivers involved in fatal accidents or stopped for impaired driving The World Health Organization concluded: Additional consideration needs to be...
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Lecture 26 - Final Lecture 26 Post Cannabis Debate +...

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