Lecture 21

Lecture 21 - Lecture 21 Neurobiology of Relapse Key...

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Lecture 21 – Neurobiology of Relapse
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Key Concepts FILM – Through a Blue Lens disinhibition via inhibition of GABA release relapse model in animals – reinstatement Bossert et al., 2011 – Nature Neuroscience theories of opiate addiction clinical issues - lethal nature of heroin addiction (HIV, HepC, risky behaviour, drug interactions)
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Mesocorticolimbic DA neurons form a crucial drug-sensitive component of reward circuitry. Most drugs of abuse activate DA neurons, at various anatomic levels,via different receptors (GABA, nAChR, NMDA). The DA signal is transmitted to other brain regions via enkephalinergic and GABAergic neurons from the NAcc.
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Reminder – Inhibitory Actions of Opioids Opiate receptors have an inhibitory action by increasing K + conductance (hyperpolarization of post- synaptic cells) Mechanistically, opioids act presynaptically primarily on glutamate and GABAa neurons to exert a change in neurotransmitter release Presynaptic inhibition exerted by endorphins or other
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Lecture 21 - Lecture 21 Neurobiology of Relapse Key...

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