Lecture 18

Lecture 18 - Lecture 18 Etiology and Treatment of Tobacco...

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Lecture 18 Etiology and Treatment of Tobacco Dependence Key Concepts LeFoll study on sensitization and conditioning Genetic factors in tobacco dependence Does smoking meet DSM-IV criteria for substance dependence? Why is it difficult to quit smoking? pharmacological effects of smoking + withdrawal Smoking cessation treatments Student Presentation Vaccines against cocaine and nicotine (Richard & Virginia)
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Sensitization LeFoll et al. 2003 found that repeated nicotine injections in the same environment produced sensitization nicotine preferentially increased DA levels in the shell region of the NAcc (ventral striatum)
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Context-Dependent Effects Animals received saline (white bars) or nicotine (dark bars) in their home cages (unpaired condition), or a specific environment (activity cages, paired environment) for 5 days On the final test day, they all received saline injections in the activity cages Conclusion?
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b - Receptor autoradiography showed that there was higher D3 receptor binding in the NAcc shell in the nicotine treated animals c - D3 receptor binding was significantly increased in rats exposed to the nicotine-paired environment
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Summary - LeFoll et al. 2003 LeFoll et al. 2003 found that repeated nicotine (0.5mg/kg) in a specific environment, produced progressive increases in locomotor activity in rats. This is called context-dependent behavioural sensitization sensitization was accompanied by increased D3 receptor mRNA levels, as well as increased D3 receptor density in the NAcc shell D3 overexpression may be a neuroadaptive process leading to sustained increases in DA neurotransmission in some brain regions
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Do you think that chronic cigarette smoking would meet DSM-IV criteria for a diagnosis of substance dependence?
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Genetic Factors in Tobacco Dependence
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however results have generally been inconsistent. Sullivan etal. (2008) and DeCode study (2008) do
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This note was uploaded on 04/26/2011 for the course PSYT 301 taught by Professor Kathryngill during the Winter '11 term at McGill.

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Lecture 18 - Lecture 18 Etiology and Treatment of Tobacco...

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