Lecture 13

Lecture 13 - Lecture 13 – Psychostimulant Wrap-Up The...

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Unformatted text preview: Lecture 13 – Psychostimulant Wrap-Up The Role of Dopamine in Motivation & Conditioning Key Concepts what is the role of dopamine in drug reward and addiction? (evidence presented to date) cues associated with reinforcers, the role of dopamine (Schultz et al., 1998) cue-induced reinstatement of drug-seeking (relapse model in animals) HBO Film on relapse with Anna Rose Childress) blockade of cue-induced relapse in animal models by dopamine D3 antagonists (SB277011-A) , as well as D3 partial agonists (e.g. BP897) (Gal & Gyertyan, 2006) limbic circuitry dopamine and incentive motivation Discussion of dopamine system to date (you should know this material) neurobiology –sites of action of cocaine and amphetamines (increased synaptic dopamine neurotransmission via DAT blockade etc) evidence supporting role for dopamine in the CNS actions of psychostimulants (Lecture 11, antagonists, neurotoxins etc.) Volkow et al (2001, 2002) demonstrated that there were changes in dopamine neurotransmitter and receptor levels decreased D2 receptor binding is associated with abnormal activity in the orbitofrontal cortex (OFC) and the anterior cingulate gyrus (CG), brain regions that are involved in inhibitory control Discussion of dopamine system to date (you should know this material) neurobiology –sites of action of cocaine and amphetamines (increased synaptic dopamine neurotransmission via DAT blockade etc) evidence supporting role for dopamine in the CNS actions of psychostimulants (Lecture 11, antagonists, neurotoxins etc.) Volkow et al (2001, 2002) demonstrated that there were changes in dopamine neurotransmitter and receptor levels decreased D2 receptor binding is associated with...
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This note was uploaded on 04/26/2011 for the course PSYT 301 taught by Professor Kathryngill during the Winter '11 term at McGill.

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Lecture 13 - Lecture 13 – Psychostimulant Wrap-Up The...

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