Lecture 12

Lecture 12 - Lecture 12 - Genetic Studies of Cocaine...

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Unformatted text preview: Lecture 12 - Genetic Studies of Cocaine Dependence Key Concepts • human genetic studies of cocaine dependence – Kendler & Prescott, 1998 • animal studies – rationale for studies in mice • Gill lab research program – mapping genes for cocaine-related behaviours (e.g. intravenous self-administration (IVSA)) • epigenetics of cocaine addiction (Student Presentation by Jenny and Vera) http://www.nytimes.com/2011/02/08/healt h/08vancouver.html?_r=2&ref=drugabus eandtraffic Kendler & Prescott, 1998 (Virginia Twin Registry) Zygosity Cocaine Concordance Odds Ratio MZ Twins Use 0.543 14.2 * Abuse 0.471 40.8 * Dependence 0.348 27.6 * DZ Twins Use 0.419 6.73 * Abuse 0.08 2.7 Dependence---- *p<0.0001, Odds ratio= increased risk for outcome in co-twin Animal Studies – Strategies for Gene Discovery Gill Research Program - Phenotypes Drug/alcohol related traits (alcohol, cocaine, nicotine and morphine) • alcohol consumption • IV and operant self-administration • drug-induced activation and depression • acute and chronic tolerance, sensitization • dopamine/serotonin uptake, receptor density Anxiety-related traits • stress/novelty- induced activation • elevated plus maze (E+M) • light/dark box • stress responses Animal Studies - Why Use Mice ?Animal Studies - Why Use Mice ?...
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This note was uploaded on 04/26/2011 for the course PSYT 301 taught by Professor Kathryngill during the Winter '11 term at McGill.

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Lecture 12 - Lecture 12 - Genetic Studies of Cocaine...

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