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Lecture 12 - Lecture 12 Genetic Studies of Cocaine...

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Lecture 12 - Genetic Studies of Cocaine Dependence Key Concepts human genetic studies of cocaine dependence Kendler & Prescott, 1998 animal studies rationale for studies in mice Gill lab research program mapping genes for cocaine-related behaviours (e.g. intravenous self-administration (IVSA)) epigenetics of cocaine addiction (Student Presentation by Jenny and Vera)
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http://www.nytimes.com/2011/02/08/healt h/08vancouver.html?_r=2&ref=drugabus eandtraffic
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Kendler & Prescott, 1998 (Virginia Twin Registry) Zygosity Cocaine Concordance Odds Ratio MZ Twins Use 0.543 14.2 * Abuse 0.471 40.8 * Dependence 0.348 27.6 * DZ Twins Use 0.419 6.73 * Abuse 0.08 2.7 Dependence -- -- *p<0.0001, Odds ratio= increased risk for outcome in co-twin
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Animal Studies Strategies for Gene Discovery
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Gill Research Program - Phenotypes Drug/alcohol related traits (alcohol, cocaine, nicotine and morphine) alcohol consumption IV and operant self-administration drug-induced activation and depression acute and chronic tolerance, sensitization dopamine/serotonin uptake, receptor density Anxiety-related traits stress/novelty- induced activation elevated plus maze (E+M) light/dark box stress responses
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Animal Studies - Why Use Mice ?
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