Introduction Bioinformatics Project

Introduction Bioinformatics Project - MIMM386...

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Dr. Silvia Vidal McGill Life Sciences Complex room 3910 Phone: 398-2362 E-mail: silvia.vidal@mcgill.ca MIMM386 Bioinformatics Project 2008-2009
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OBJECTIVES 1- Introduction to bioinformatics 2- Practical information bioinformatics lab
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OUTLINE INTRODUCTION 1- WHAT IS BIOINFORMATICS? definition, applications, goal 2- WHERE DOES IT OCCUR? Some important institutions 3- HOW DOES IT HAPPEN? EXERCISE 3.2.1 BLAST 3.2.2 CLUSTAL W 3.3.3 3-D VIEWER 3.1 DATABASES NCBI databases 3.2 TOOLS for protein sequence analysis
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What is Bioinformatics? Scientific discipline resulting from the merge of biology and information sciences
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1953: Watson and Crick propose the double helix model for DNA structure 1955: First protein sequence -bovine insulin- by Sanger 1958: First integrated circuits constructed by Jack Kilby at Texas inst. 1969: ARPANET links computers at California and Utah Universities. 1971: Ray Tomlinson invents the email program 1972: First recombinant DNA molecule by Paul Berg 1977: DNA sequencing methods by Maxam & Gilbert and Sanger 1980: First complete sequence of phage Φ X174 (5300 bp) 1981: First algorithm for sequence alignment by Smith-Waterman 1986: Announcement of Human Genome Initiative and creation of SWISS-PROT 1988: Creation of NCBI 1995: Publication of the Haemophilus Influenza Genome (1.8 Mb) 1997: Publication of E coli genome (4.7 Mb) 2001: Publication of the Human Genome sequence (3000 Mbp) Some history …
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Access and Storage of information is important
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2009
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Bioinformatics comprises two main activities:
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The general goal of bioinformatics is: 1- Providing testable predictions from data and/or their manipulation 2- Needs to support data with statistics and probability calculations
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Medical sciences Genomics (humans, plants, animals, pathogens) Ecology / population genetics Functional genomics Systems biology Pharmaceutical development Molecular biology Bioinformatics is presently used in. ..
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Bioinformatics and . .. viruses genome/protein sequence analysis identify new virus/gene/protein predict protein function identify active sites, functional domains evolution 3D structure protein design identify inhibitors of protein function
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1 aaataatgta ttggctctgc aaatgcagct tcagaacaag tcccttagct gtccccaccc 61 caccctaagt caccaccctt aagcctcacc catgtggaat tctgaaactt cctttgtaga 121 aaactttgga aggtgtctgc cacattgatc ctggaatgtg tgtttatttg gggttatata 181 aatctgttct gtggaagcca cctgaagtca ggaagagatg gagggcatcc ttcaggagtg 241 agatgagacc tcatcatact tgactgtcca gcatcatctc tgagtaaggg gaccaaaaaa 301 tttatcttcc aaactaggac actttcaaga gtggaagggg gatccattaa tattttcacc 361 tggacaagag gcaaacacca gaatgtcccc gatgaagggg atatataatg gaccttcttg 421 atgtgaaacc tgccagatgg gctggaaagt ccgtatactg ggacaagtat gatttgagtt 481 gtttgggaca aggacagggg tacaagagaa ggaaatgggc aaagagagaa gcctgtactc 541 agccaagggt gcagagatgt tatatatgat tgctcttcag ggaaccgggc ctccagctca 601 caccccagct gctcaaccac ctcctctctg aattgactgt cccttctttg gaactctagg
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Introduction Bioinformatics Project - MIMM386...

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