ENDOOOOOOOO - Hormone Growth Hormone Releasing Hormone...

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Hormone Abbreviation Gland of Origin Action GHRH Hypothalamus GH Ghrelin Prolactin PRL Growth  Hormone  Releasing  Hormone Stimulates GH release and  synthesis (by increasing cAMP  levels) - main regulator of GH  release under normal conditions Growth  Hormone somatotrophic  cells of anterior  pituitary increased production of insulin- like growth factors (IGFs),  promote growth of body tissues,  organ size/function, increase  protein synthesis, DNA  synthesis, RNA synthesis, cell  size and number, acute = mainly  metabolic, enhancing body  protein, uses up fat stores and  stimulates release of GH and  increase release of GHRH lactotroph cells of  anterior pituitary development of breast during  pregnancy, neural development  of fetus, increasing milk  production after birth
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ADH Oxytocin partuation and lactation TRH TSH Anti-Diuretic  Hormone  (Vasopressi n) Supraoptic  nucleus of the  posterior pituitary Paraventricular  nucleus of the  posterior pituitary Thyroid  Releasing  Hormone hypothalmus,  synthesized by  neurons from the  stimulate synthesis and relase of  TSH Thyroid  Stimulating  Hormone synthesized and  secreted by  thyrotrophic cells  of anterior pituitary synthesize and release thyroid  hormones and increases the size  of thyroid gland
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T3 and T4 CRH Thyroid  Hormone follicular cells of  thyroid gland and  synthesized by  iodine promote an increase in metabolic  rate (increased O2 consumption  and heat production), tissue  grwoth and brain development  OVERALL INCREASE MBR,  increase in erythropoietin  production, increase muscle  speed and ITS IMPORTANT  FOR NORMAL DEVELOPMENT  AND FUNCTION OF CNS AND  FOR NORMAL MENTAL AND  EMOTIONAL FUNCTION Corticotropi n Releasing  Hormone synthesized by  antrerior portion of  paraventricular  nucleus and stored  in median  eminence increases the synthesis/release  of ACTH and stimulates pro- opiomelanocorticotrophin  (POMC)
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ACTH Aldosterone Adrenocortic otrophic  Hormone synthesized and  secreted by  corticotrophic cells  of anterior pituitary  from large  precursor  molecule = POMC  increase synthesis of  glucocoricoids (cortisol) and  androgens by making cholestrol  into pregnenolone, increase  cholesterol uptake, transport  cholesterol into mitochondria,  activation of cholesterol  esterases, activates synthesis of  steroidal acute regulatory protein  (StAR) which activates a  cholesterol channel in  mitochondria (zona  reticularis/zona fasciculata)  SHORT TERM - conversion of  cholesterol into pregnenolone  and LONG TERM = transcription  zona glomerulosa  where cells have  aldosterone  synthase and two  main regulatory  steps are  cholesterol to  pregnenolone and  deoxycorticosteron e to aldosterone
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This note was uploaded on 04/28/2011 for the course PSIO 201 taught by Professor Stanescu during the Spring '08 term at University of Arizona- Tucson.

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ENDOOOOOOOO - Hormone Growth Hormone Releasing Hormone...

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