2007 #2 - Chemistry 223b 2007 Term Test #2 Page 1 Before...

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Chemistry 223b 2007 Term Test #2 Page 1 Before you start, please ensure that you have entered onto the Scantron: Exam code 111 Student number Official name Section code (001 = Kerr, 002 = Lee) 1. With the assistance of the known, three-dimensional structure of an enzyme, a pharmaceutical company designed a drug that inhibited the enzyme. What is this method of drug discovery referred to as? A) Serendipitous discovery B) Structure-activity relationship studies C) Combinatorial chemistry D) High-throughput screening E) Structure-guided drug design 2. Which one of A – E correctly describes a drug that is used off-label ? A) One that is counterfeit B) One that is used for other than its intended purpose C) One that has been fast-tracked D) One that is sold by Canadian internet pharmacies to Americans E) One that has a label missing from its bottle
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Chemistry 223b 2007 Term Test #2 Page 2 3. Which one of the following does NOT constitute an in vitro experiment? A) Testing the ability of a drug to kill a bacterial culture B) Measuring the rate at which bacteria transport a drug across the cell membrane C) Determining whether a drug inhibits an isolated enzyme D) Studying the toxicity of a drug towards a culture of human cells E) Testing the efficacy of a drug in mice 4. Which one of the following predominantly investigates the ADMET properties of a investigational new drug in a small group of human subjects? A) Phase I trials B) In vitro studies C) Animal studies D) Preclinical studies E) Phase II trials 5. In the second step of folic-acid biosynthesis, an amide is formed from a carboxylate group and an amine. Why is ATP required for this reaction? A) It removes toxic ATP from the cell B) It converts the carboxylate into a more-reactive acid derivative C) It deprotonates the amine to make it a better nucleophile D) It protonates the carboxylate to make it a better nucleophile E) It modifies the pK a of the amino group
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Chemistry 223b 2007 Term Test #2 Page 3 6. Allura Red (Red #40), shown below, is a red dye that is found in candy and mouthwash. Which compounds are formed when it is metabolized via reduction? OCH 3 NaO 3 S N N HO SO 3 Na OCH 3 NaO 3 S OCH 3 NaO 3 S NH 2 3 NaO 3 S N N 3 H 2 N SO 3 NN SO 3 12 3 45 6 A) 2 and 5 B) 1 and 6 C) 2 and 4 D) 3 and 4 E) 1 and 5
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Chemistry 223b 2007 Term Test #2 Page 4 7. A red solution of Allura Red was placed in a UV-visible spectrophotometer, and an absorption spectrum spanning the region of visible light was collected. What colour of light corresponds to the wavelength of maximum absorption?
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2007 #2 - Chemistry 223b 2007 Term Test #2 Page 1 Before...

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