BIOL1510_module5_4_human_evolution

BIOL1510_module5_4_human_evolution - Office Hours This Week...

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Office Hours This Week A112 Cherry Emerson Tuesday, Thursday 9-12pm Wednesday 2-4pm Taylor’s Defense – Wednesday 12:30 PM MS&E Building, room 3201A
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Human Health and Evolution Balancing Selection HIV/CCR5 Sickle Cell Anemia Cystic Fibrosis
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HIV infects T cells via CD4 and CCR5 cell surface receptors
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Frequency of CCR5-delta32 allele in different human populations Northern Europe 10% Central Asia 2% Asia, Africa 0% CCR5 is a receptor for signaling molecules. CCR5-delta32 homozygotes are healthy, but have greater susceptibility to West Nile virus. CCR5-delta32 allele arose over 5,000 years ago.
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Q: If the CCR5-delta32 allele frequency is 0.10, what percentage of individuals will be homozygous for this deletion and highly resistant to HIV infection? A. 10% B. 20% C. 1% D. 2% E. 5%
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Q: What are plausible hypotheses to explain the high frequency of the CCR5-delta32 allele among Northern Europeans? A. Heterozygote advantage B. Genetic drift C. Founder effect D. Resistance to Black Death during the Middle Ages E. Selection for HIV resistance
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This note was uploaded on 05/01/2011 for the course BIOL 1510 taught by Professor Jungh.choi during the Spring '07 term at Georgia Institute of Technology.

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BIOL1510_module5_4_human_evolution - Office Hours This Week...

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