BME 100L Spring 2011 Syllabus

BME 100L Spring 2011 Syllabus - BME 100L Modeling Cellular...

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BME 100L. Modeling Cellular and Molecular Systems Spring 2011 Lecture: Tu Th 10:05 to 11:20 AM in Hudson 208 Lab: Th 1:15-3:15 PM or 4:25-6:25 PM in Teer P013 This course is an introduction to mathematical modeling of kinetic processes in cellular and molecular systems. It also discusses applications of these models in biotechnology. The topics include: thermodynamics, chemical equilibrium and kinetics, enzyme kinetics, DNA denaturation and rebinding, regulation of gene expression, and signal transduction in cells. Laboratory experiments are also included to help learn the concepts in the class. Course objectives 1. Introduce topics of chemical thermodynamics and kinetics with applications to biological systems, including: a. Calculate state variables (e.g., H, S, and G) of closed systems (e.g., ideal gases and ideal solutions) at any temperature b. Calculate changes of state variables (e.g., H, S, G) in chemical reactions c. Use 1st and 2nd laws in thermodynamics to analyze chemical reactions d. Kinetic analysis of enzyme reaction e. Perform kinetic analysis of simple reaction networks in biological systems f. Use quasi-steady and quasi-equilibrium concepts to simplify kinetic models 2. Develop kinetic models of molecular events in cells based on known mechanisms 3. Use MATLAB to develop and apply models, including numerical simulations of reaction kinetics 4. Perform experiments that demonstrate concepts presented in class 5. Develop written communication skills Prerequisites: Mathematics 103 and Biology 101L or equivalent. Required
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BME 100L Spring 2011 Syllabus - BME 100L Modeling Cellular...

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