BIO250 Spr11-31

406 recall characteristics of fatty acid biosynthesis

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Unformatted text preview: 4.06 Recall: Characteristics of Fatty Acid Biosynthesis As is typical for biosynthetic pathways, the As reaction sequences are reaction Endergonic Reductive And they employ ATP as the metabolic energy source The electron carrier NADPH as reductant Large and sophisticated enzyme complexes 11.4.06 11 Fatty Acid Synthase: From Subunits to Domains Remarkably, although each activity Remarkably, arose separately at the bacterial level, by the time vertebrates evolved, a single very large protein was enough to encompass all of the activities of the fatty acid synthase. synthase. 12 4e Fig. 21-7 Fig. 21-3 11.4.06 Cofactors as Biological Tethers - A general principle Lipoate – “swinging Lipoate arm” of pyruvate dehydrogenase dehydrogenase Biotin – carries CO2 in an important anaplerotic reaction anaplerotic Pantothenate (Vit B5) – tethers the growing chain in fatty acid synthetase synthetase 11.4.06 1...
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This note was uploaded on 05/01/2011 for the course BIO 250 taught by Professor Culver during the Spring '08 term at Rochester.

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