ch15(glucReg)n2-jdr - 4/11/2011 Glycogen Metabolism Storage...

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4/11/2011 1 Glycogen Metabolism Storage polymer Osmotic advantage Anaerobic glycolysis yields 2 ATP/glucose converted to lactate Glucose from glycogen is already phosphorylated (glucose-1-P), so anaerobic glycolysis yields 3 ATP/glucose Rapid delivery of phosphorylated glucose: G-1-P Glycogen (n) UDP -Glucose Glycogen (n-1) Glycogenolysis Glycogen Synthesis Glycogen (n-1) UTP PP 2P
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4/11/2011 2 total body glycogen has energy content = 3800 kJ (total body glucose has energy content = 330 kJ) 2 major storage sites: •liver (~ 10% wt) •skeletal muscle (1-2%) 15-24 Glycogen granules in hepatocyte 15-33 Non-reducing ends Reducing end ( a 1 6)linkages
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3 15-25 Glycogen breakdown by glycogen phosphorylase Note: this is not hydrolysis, but phosphorolysis Glycogen breakdown Glucose-6-P 1 2a 3 15-26 Glucose-6-phosphatase (liver) P i 4 glucose phosphoglucomutase 2b glycolysis The liver’s job is to provide blood glucose for other organs. (Muscle cells)
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This note was uploaded on 05/01/2011 for the course CH 53890 taught by Professor Raymonds during the Spring '09 term at University of Texas at Austin.

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ch15(glucReg)n2-jdr - 4/11/2011 Glycogen Metabolism Storage...

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