Controlling Microbial Growth in the Body (1)

Controlling Microbial Growth in the Body (1) - Controlling...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Controlling Microbial Growth in the Body: Antimicrobial Drugs The History of Antimicrobial Agents Paul Ehrlich discovered the first chemotherapeutic agent, arsenical compound effective against syphilis called Salvarsan. The first antibiotic discovered was penicillin by Alexander Fleming released from Penicillium (mold). Mechanisms of Antimicrobial Action Antimicrobial drugs can be categorized into several groups according to their mechanisms of action. o Drugs that inhibit cell wall synthesis o Drugs that inhibit protein synthesis o Drugs that disrupt the cytoplasmic membrane o Drugs that inhibit general metabolic pathways o Drugs that inhibit nucleic acid synthesis o Drugs that block a pathogen attaching to its host A. I NHIBITION   OF   CELL   WALL   SYNTHESIS Most common agents act by preventing cross-linkage of NAM subunits. Most prominent in this group are beta-lactams such as penicillins and cephalosporins whose functional groups are called beta- lactam (β- lactam) rings. These drugs eventually cause the cell to lyse. Penicillin G is currently the most popular penicillin antibiotic. Other types are penicillin F and penicllin G.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern