Aritcle 1 answer

Aritcle 1 answer - Group 5 Daniel Tevin 003651296 Wan Ho...

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Group 5 Daniel Tevin 003651296 Wan Ho Lam 203985091 Leong, Hio Weng 503827905 Statistics 101A Professor Esfandiari Article one Winter 2011 Title: Comparison of the Progressive Cortical Gray Matter Loss in Childhood- Onset Schizophrenia With That in Childhood Onset-Atypical Psychosis. 1) What is the design of the study? (True experimental involving blocking, double blind, etc.) This study is designed as controlled and not double blind. The research is based on using a control group to compare with the experimental group on various factors. All groups have similar baseline characteristics. 2) What is/are the major questions that they are trying to answer? Does more cortical GM loss occur in patients with child-onset schizophrenia than adolescents with multidimensional impairment (MDI) or subjects with normal brain development? 3) What are the independent and outcome variables of the study and how were they measured? The independent variable and outcome variable is the cortical GM loss occurs in patients with COS but not in adolescents with atypical psychoses. It is measured through anatomical brain MRI was performed at baseline and follow-up in 19 patients in the MDI group, and they are measures by percentage change.
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Group 5 Daniel Tevin 003651296 Wan Ho Lam 203985091 Leong, Hio Weng 503827905 4) Describe the subjects. The subjects are categorized in three groups: COS, MDI, and Control. COS: These patients met the DSM-IV criteria for schizophrenia with the onset of psychosis before the 13 th birthday. These patients also participated in a prospective brain MRI developmental study. This group excluded patients with a history of substantial medical problems, substance abuse, or an IQ score lower than 70 prior to the onset of psychotic symptoms. MDI: This is mainly a group of subjects excluded from the COS group. These patients had transient psychotic symptoms, but were primarily impaired by brief disruptive behaviors that occurred infrequently. They were put into this group by two child psychiatrists using clinical and structured interviews. Patients also reported hallucinations and delusions. These patients underwent assessment clinically and neurobiological.
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