Lecture 11 - BIOL104-04 Principles of Biology I September...

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BIOL104-04 Principles of Biology I September 17, 2010 Lecture #11 Ch 15 Genes & How They Work
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Central Dogma of Cell Biology
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Transcription is the synthesis of RNA from a DNA template
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Bacterial RNA Polymerase The enzyme that “reads” the DNA sequence and makes the mRNA chain Catalyzes the formation of the phosphodiester bond at the 3’ end of the RNA chain with the new ribonucleotide Does NOT require a primer
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Sigma subunit of Bacterial RNA polymerase • Regulatory subunit • Guides RNA polymerase to specific sites on the DNA where transcription should begin • The specific sections of DNA where transcription begins are called promoters
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Transcription initiation occurs at promoters Located on the non-template strand Bacterial promoter 40-50 bases (nucleotides) long +1 transcription start site -10 box -35 box +1
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Transcription bubble moves along ~50 bases/second
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Transcription terminates when a hairpin forms
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coupled in prokaryotes
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This note was uploaded on 05/03/2011 for the course BIOL 104 taught by Professor Bray-speth during the Fall '11 term at Saint Louis.

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Lecture 11 - BIOL104-04 Principles of Biology I September...

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