Lecture 24 - BIOL104-04 Principles of Biology I October 25,...

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BIOL104-04 Principles of Biology I October 25, 2010 Lecture #24 Ch 9 Cell Communication
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Types of receptors • Intracellular receptors – Hydrophobic ligand • Cell surface receptors – Chemically gated ion channels – Enzymatic receptors – G protein-coupled receptors
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Intracellular receptor • Cytoplasm • No extracellular binding site • Hydrophobic ligand • Example – Steroid receptors, vitamin D, thyroid hormone
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Chemically gated ion channel • Multipass transmembrane protein • Can form a pore • Ligand binding causes pore to open or close • Example – Neurons
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Chemically gated ion channel
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Enzymatic receptor • Single pass transmembrane protein • Binds ligand extracellularly • Catalyzes response intracellularly • Example – Phosphorylation of protein kinases
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Enzymatic receptor
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G-protein coupled receptors • Seven-pass transmembrane protein • Cytoplasmic binding site for G protein • Binding of ligand causes G protein to bind GTP • G protein + GTP detach to deliver the signal
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This note was uploaded on 05/03/2011 for the course BIOL 104 taught by Professor Bray-speth during the Fall '11 term at Saint Louis.

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Lecture 24 - BIOL104-04 Principles of Biology I October 25,...

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