Lecture 25 - BIOL104-04 Principles of Biology I October 27,...

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BIOL104-04 Principles of Biology I October 27, 2010 Lecture #25 Ch 16 Control of Gene Expression (Sections 16.1, 16.2, 16.6, & 16.7)
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Control at the level of transcription • RNA polymerase needs to bind to DNA to initiate transcription • Binds at a promoter
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Transcription initiation occurs at promoters Located on the non- template strand Bacterial promoter 40-50 bases (nucleotides) long +1 transcription start site -10 box -35 box +1
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Regulatory proteins affect the ability of RNA polymerase to bind to the promoter • Regulatory proteins – Bind to specific nucleotide sequences – 10-15 nucleotides in length – Hundreds have been identified – Each provides a binding site for a specific protein
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Binding of a regulatory protein • Can BLOCK transcription by getting in the way of RNA polyermase • Can STIMULATE transcription by facilitating the binding of RNA polymerase to the promoter
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Control of gene expression • Prokaryotes – Adjust the cell’s activities to changes in the
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Lecture 25 - BIOL104-04 Principles of Biology I October 27,...

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