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Lecture 33 - BIOL104-04 Principles of Biology I Lecture#33...

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BIOL104-04 Principles of Biology I November 17, 2010 Lecture #33 Ch 13: Chromosome mapping & the Meiosis-Inheritance Connection
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Genetic variation Crossing over Independent assortment – Separation & distribution of homologous chromosomes • Fertilization
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Reciprocal Cross A set of two matings Mother’s phenotype in the first cross is the father’s phenotype in the 2nd cross Mendel tried a reciprocal cross with pea shape
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Drosophila melanogaster Fruit fly Small size Easy to maintain Short reproductive cycle (10 days) Abundant offspring (few hundred/mating) Phenotypic variation among individuals
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Wild type – Most common phenotype • Mutant – Different from wild type – Difference is due to a mutation
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Wild type Mutant
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Reciprocal cross For Mendel & garden pea shape reciprocal crosses were same BUT for fly eye color they were not the same Red-eye female x white-eye male – F1 progeny all red eyes White-eye female x red-eye male – F1 progeny – Females red eyes – Males white eyes
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Discovery of sex chromosomes Observation in beetles – Females had 20 large chromosomes – Males had 19 large and 1 small
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