Lecture 37 - BIOL104-04 Principles of Biology I December 3...

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BIOL104-04 Principles of Biology I December 3, 2010 Lecture #37 Ch 52 The Immune System Sections 52.1 - 52.4
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What does the immune system do?
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The immune system • Primary lymphoid organs – Bone marrow – Thymus • Secondary lymphoid organs – Spleen – Lymph nodes – MALT mucosa-associated lymphoid tissue
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Two arms of the immune response • Innate immune response – Fast (minutes or hours) – Same every time – No memory response – Barriers • Adaptive immune response – Slower (days) – Very diverse – Memory response
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Innate immune response
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Innate immune response • Pattern recognition receptors – Transmembrane proteins – Plasma membrane – Intracellular membrane • Detect molecular patterns in pathogens that are not in host cells • Quite a few different receptors – Each encoded by a single gene • Cause a signaling cascade that activates cells of the innate response
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Pattern recognition receptors
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Leucocytes “White cells” • Macrophages • Neutrophils • Mast cells • Natural Killer cells • B lymphocytes • T lymphocytes
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Mast cell • Release chemical messengers – Restrict blood flow at wound site – Increase blood flow near wound • Allergies • Innate response
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Polymorphonuclear cell • “Neutrophil” • 1st cells to arrive at wound or site of infection • Kill pathogens • Ingest pathogens • Innate response
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This note was uploaded on 05/03/2011 for the course BIOL 104 taught by Professor Bray-speth during the Fall '11 term at Saint Louis.

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Lecture 37 - BIOL104-04 Principles of Biology I December 3...

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