Lecture 38 - BIOL104-04 Principles of Biology I December 6,...

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BIOL104-04 Principles of Biology I December 6, 2010 Lecture # 38 Ch 52 The Immune System
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Announcements • Final exam • Wednesday 12/8 10:00 am • Lee Auditorium • Please do not sit in the last three rows
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Questions • How many pathogens are there? • How can the immune system recognize so many different pathogens?
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BCR vs. TCR
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Variable regions Comparison of light chain sequence of 77 different Ab molecules Variability index = # Ab that had a different amino acid at a certain position/ frequency of the most common amino acid at that position
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Variable regions • Lots of variability means the adaptive immune response can recognize MANY different antigen • How can the genome encode for so many different variable regions?
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Gene Recombination – 2 separate genes encode for the light chain • One gene for the variable region • One gene for the constant region – Genes are rearranged during the course of B-cell differentiation – Light chain locus – 40 V segments (Variable) – 5 J segments (Joining) – C segment (Constant)
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Lecture 38 - BIOL104-04 Principles of Biology I December 6,...

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