BIOL 426_ 1 - Introduction - Developmental Neurobiology...

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Developmental Neurobiology Biol 426 Instructor: Gong Chen Department of Biology Pennsylvania State University
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Who am I? http://www.bio.psu.edu/directory/guc2
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Goal Cover broad topics relating to the development of the brain—from embryo to aging brain Focus on some hot topics and dig in depth: teaching fundamental principles Integrate current exciting research progress into lectures: how principles are established Interactive: students are encouraged to raise questions during and after the class Fun: interest is the best friend of learning Integrate our own research
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Exams Multiple choices Final essay Extra credit
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Overview of Highlights Neural stem cell, iPSC, direct conversion Axon guidance Synapse formation and plasticity Neurodevelopmental disorders: autism and schizophrenia Neuron-glia interaction Programmed neuronal death Learning and memory Alzheimer’s disease: still puzzling!
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New Technology: Brainbow http://amazingdata.com/mediadata6/Image/amazing_fun_featured_ 2 Jeff W. Lichtman’s and Joshua R. Sanes’ groups, Harvard Livet, J. et al. Nature 450, 56-61 (2007). Multiple copies of fluorescent proteins : yellow, red, cyan, orange , green.
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Optogenetics: Channelrhodopsin http://syntheticneurobiology.org/ projects/display/52/20 http://www.brain.imi.i.u-tokyo.ac.jp/ research_new/tabuchi_graphic.png Karl Deisseroth, Stanford Ed Boyden, MIT Halorhodopsin Cl - H + , Na + , K + , Ca 2+
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Large scale sequencing
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This note was uploaded on 05/03/2011 for the course BIOL 426 taught by Professor Profgongchen during the Spring '08 term at Pennsylvania State University, University Park.

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BIOL 426_ 1 - Introduction - Developmental Neurobiology...

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