BIOL 426_ 5 - Neural Stem Cell - Neural Stem Cell Part I:...

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Neural Stem Cell Part I: Overview
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Materials Neural Stem Cells, by Bottenstein: Chapter 4-6 for complementary reading Stem Cells Handbook, By Sell Slides indicated portion Exams will be confined within the class material Reserved in Life Science Library Paterno, 4 th floor Can’t check it out
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Why Study Stem Cells? To understand the cycle of life To study how adult tissues get renewed To explore the use of stem cells as a way of tissue repairing, i.e., “stem cell therapy”. Many diseases don’t have a good treatment today. Stem cells offer a great hope of replacing dead cells or even a failed organ with a newly created one. Treatment for Parkinson’s disease is a good model: grafting stem cells into patients, generate new dopaminergic neurons and relieve symptom up to 10 years.
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2003 Britain becomes the first country to issue research licences for human embryonic cloning to create stem cells. It specifies therapeutic, not reproductive, cloning. 2004 California voters voted to support Proposition 71, designating $3 billion for stem cell research over 10 years. 2004 Harvard University established stem cell research institute to use private fund to do stem cell research. 2004 Britain announces the first embryonic stem cell bank. Many other countries support stem cell research. Stem Cell Research: Hot Issue
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Stem Cell Research Milestones 1960s: Research begins on stem cells taken from adult tissue 1968: Adult stem cells used to treat immunodeficient patient 1981 UCSF's Gail Martin co-discovers embryonic stem cells in mice, and coins the term “embryonic stem cell”. 1998: US scientists James Thomson et al. at University of Wisconsin grow stem cells from human embryos and germ cells, establishing cell lines still in use today 2001: Embryonic stem cell turned into a blood cell 2007: Reprogram skin cell into pluripotent stem cell Photo by: Jeff Miller James Thomson University of Wisconsin- Madison
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Stem Cell Division Early development Late development Stem cells handbook, By Sell
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http://www.umdnj.edu/gsbsnweb/stemcell/scofthemonth/CSCsci.htm Self renew
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“All cells come from cells.” --Rudolph Virchow A stem cell is a cell that can divide almost infinitely and make many or all other specialized cells in the body. Germinal stem cells persist in the adult to allow the cycle of life to
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This note was uploaded on 05/03/2011 for the course BIOL 426 taught by Professor Profgongchen during the Spring '08 term at Pennsylvania State University, University Park.

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BIOL 426_ 5 - Neural Stem Cell - Neural Stem Cell Part I:...

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