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Unformatted text preview: PSYCHOPHARM I N TRODUCT ION Non-Selective - if the Activation on subtypes is the same as every normal receptor Ex. The activation of a dopamine (DA) transmitter would be the same for that transmitter and any subtype (D1, D2, D3, etc.) A. In other words, the brain/drug cannot distinguish between subtypes of the same transmitter and therefore affects all of them equally because it is non- selective SSRI -selective serotonin reuptake inhibitor A. Reuptake blockade (of a transmitter) -when you want a drug to affect only a certain area Ex. Dopamine -therefore dopamine levels will rise if it is blocked -and will rise everywhere in the brain and the body i. In other words, all dopamine receptors will be activated NOT individual subtypes 1. Most will happen where you dont want it to in the brain -this is called a side effect Agonist -actives a receptor or a receptor subtype -mimics the transmitter -depends on the subtype of which it binds This can increase or decrease the amount of a particular transmitter in the brain/body...
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- Spring '11