PSY 356 pharmacodynamics 1

PSY 356 pharmacodynamics 1 - Phamacodynamics binding cite...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Phamacodynamics - binding cite, receptor, etc. -involves exploring the mechanisms of drug action that occur at the molecular level -the study of what the drug does to the body (Pharmacokinetics -the study of what the body does to the drug) A. To produce and effect, a drug must bind to and interact with specialized receptors, usually located on cell membranes usually located on the surface on neurons in the brain A. Drug-receptor binding -The occupation of a receptor by a drug lead to a change in the functional properties of the neuron, result in the drug's characteristic pharmacological response a. Both ionic and reversible in nature with positive and negative charges on carious portions of the drug molecule and the receptor protein attracting one to the other i. The strength of ionic attachment is determined by the fit of the three- dimensional structure of the drug to the three-dimensional site on the receptor b. When a psychoactive drug binds to a receptor and thereby alters (activates or blocks) the normal functions of that receptor, the neuronal response to the drug is one of two types: i. An immediate response to the presence of the drug on the receptor a. Follow from the acute binding of a drug to its receptor with initiation of an immediate neuronal (and behavioral response) ii. When the drug is given over a longer period of time, long-term changes in the properties of the receptors resulting the long-term changes in neuronal, brain, and behavioral functioning a. Longer-term responses to a drug require that a drug be taken continually over a period of time i. The drug is contact with its receptors for days to months and as a result, neurons "adapt" to the presence of drug, resulting in long- term changes in neuronal functioning b. Some long-term adaptations to the presence of drug can be harmful -drug "dependency" can follow long-term use and cause withdrawal symptoms after discontinuation Receptors for Drug Action -drugs exert their effect by forming reversible ionic bonds with specific receptors A. Receptor -fairly large molecule (usually a protein) on the surface of or within a cell that is the site (or sites) where biologically active, naturally occurring endogenous compounds (called transmitters or modulators) produce their normal biological effects. a. Only one neurotransmitter may be specific enough to fit or bind to a specific receptor protein. For example, if only serotonin binds to a specific receptor, that protein is called a serotonin receptor i. But although the receptor is specific for serotonin, serotonin (as a neurotransmitter) also binds to other structurally different receptors a. More than 15 different serotonin receptor proteins have been
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

PSY 356 pharmacodynamics 1 - Phamacodynamics binding cite...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online