PSY 356 psychedelics 2

PSY 356 psychedelics 2 - PSYCHEDELICS CONTINUED...

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PSYCHEDELICS CONTINUED Serotoninlike Psychedelic Drugs –LSD, Psilocybin and Psilocin, DMT, Bufotenine, Ololiuqui, Harmine, BZP and TMFPP A. 5-HT 2A receptor agonist 1. In medial prefrontal cortex and anterior cingulated cortex (areas involved in producing hallucinations) B. Effects – disturbances in thinking, illusions, elementary and complex visual hallucinations, impaired ego functioning LSD A. Extremely small dosages because of high potency–induces remarkable psychological change in a person, enhancing self-awareness and altering internal reality, while causing relatively few alterations in the general physiology of the body 1. Usually found on small pieces of paper, back of stamps, sugar cubes, etc. B. Discovered by Albert Hofmann on accident when studying Ergot (natural product derived from fungus) C. Pharmacokinetics –taken orally, distributed rapidly and efficiently throughout the body, crosses BBB and placenta easily (largest amounts of LSD can be found in liver where drug is metabolized before it is excreted) 1. Can be detected in small amounts in urine –metabolite found in much larger amounts D. Very high TI –nonlethal compound, low level of toxicity
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This note was uploaded on 05/05/2011 for the course PSY 356 taught by Professor Simson during the Spring '11 term at Miami University.

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PSY 356 psychedelics 2 - PSYCHEDELICS CONTINUED...

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