PSY 356 psychedelics 3

PSY 356 psychedelics 3 - PSYCHEDELICS CONTINUED...

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PSYCHEDELICS CONTINUED Glutaminergic NMDA Receptor Antagonists –PCP, Ketamine, DXM A. Psychedelic dissociative anesthetic, analgesic, amnestic, and psychedelic B. Structurally different from all other psychedelic agents and do not involve actions on 5-HT, Ach, or DA C. Effects 1. Have schizophrenia-like reactions (especially with increased, more frequent doses) a. Both positive and negative symptoms 2. Suppression of pain 3. Does not product classic anesthetic state a. Animals look awake -eyes are open and can blink 4. Humans get a drunken-like state (intoxication) a. One of the effects of alcohol is NMDA blocker too 5. Increase in energy 6. Distorted sensorium a. Pain information is not coming through as it normally does i. Blunted ii. Humans exhibit a fishbowl effect Can appear to do super human deeds because they cannot feel it D. Inhibit NMDA receptors by 1. Blockade of the open channel by occupying a sit within the channel in the receptor protein 2. Reduction in the frequency of NMDA channel opening by drug binding to a second attachment
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This note was uploaded on 05/05/2011 for the course PSY 356 taught by Professor Simson during the Spring '11 term at Miami University.

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PSY 356 psychedelics 3 - PSYCHEDELICS CONTINUED...

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