18-19Signal Transduction

18-19Signal Transduction - Signal Transduction Some...

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1 Signal Transduction Some concepts that will be covered: What is signal transduction? Characteristics of signal transduction Signal Molecule or Ligand Second messengers Protein modifications Amplification Feedback G-protein Coupled Receptors What are G-proteins? b -Adrenergic Signaling Cascade a -Adrenergic Signaling Cascade Desensitizing the response Response Recovery Readings pages 381-391 pages 399-402 Problems: pages 405-407 #4, #5, #6, #13 Explore these links for more about Signal transduction One Two Signal Transduction
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2 Signal Transduction Paradigm single event amplification many downstream targets activated Signal Transduction Cascade Signal Transduction Often Leads to Covalent Modifications of Proteins Phosphorylation/Dephosphorylation Ubiquitination Sulfation Myristolation Acetylation These modifications can lead to alterations in: levels of a protein activity of a protein affinity to a target location of a protein Protein Kinases: Universal Target of Cell Signaling In eukaryotes this occurs principally on OH groups of ser, thr and tyr residues Some protein kinases phosphorylate on histidine residues example of a tyrosine kinase: insulin receptor
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3 Protein Kinases: Universal Target of Cell Signaling Protein Kinases: Universal Target of Cell Signaling
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This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

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18-19Signal Transduction - Signal Transduction Some...

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