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30Pentose Phosphate Pathwayu

30Pentose Phosphate Pathwayu - This in turn causes...

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1 Pentose Phosphate Pathway Two major functions: 1. Make NADPH for biosynthesis 2. Make Ribose 5-phosphate for the synthesis of DNA and RNA This pathway is found in all organisms Readings in Textbook : pages 577-581 pages 583-587 Practice Problems : Pages 590-591- #9, 11, 12 Two phases to the Pentose Phosphate Pathway 1. Oxidative generation of NADPH 2. Non-oxidative interconversion of sugars 2 NADPH generated during conversion of glucose 6- phosphate to ribulose 5- phosphate
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2 Phase I (oxidative) Glucose 6-Phosphate Dehydrogenase Deficiency Makes organism more susceptible to oxidative damage from Reactive Oxygen Species because NADPH is needed to generate reduced glutathione used to combat ROS stress
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