30Pentose Phosphate Pathwayu

30Pentose Phosphate Pathwayu - This in turn causes...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Pentose Phosphate Pathway Two major functions: 1. Make NADPH for biosynthesis 2. Make Ribose 5-phosphate for the synthesis of DNA and RNA This pathway is found in all organisms Readings in Textbook : •pages 577-581 •pages 583-587 Practice Problems : •Pages 590-591- #9, 11, 12 Two phases to the Pentose Phosphate Pathway 1. Oxidative generation of NADPH 2. Non-oxidative interconversion of sugars 2 NADPH generated during conversion of glucose 6- phosphate to ribulose 5- phosphate
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Phase I (oxidative) Glucose 6-Phosphate Dehydrogenase Deficiency Makes organism more susceptible to oxidative damage from Reactive Oxygen Species because NADPH is needed to generate reduced glutathione used to combat ROS stress
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: This in turn causes hemolytic anemia because red blood cells are particularly susceptible to oxidative damage Makes people less susceptible to malaria parasite because the parasites require reduced glutathione Cells generally need NADPH but not ribose 5-phosphate so there is a link between pentose phosphate pathway and glycolysis 3 Five Carbon sugars converted to 2 six carbon and 1 three carbon sugar 3 Cells generally need NADPH but not ribose 5-phosphate so there is a link between pentose phosphate pathway and glycolysis sum of reactions Glucose 6-Phosphate 4 5...
View Full Document

This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

Page1 / 5

30Pentose Phosphate Pathwayu - This in turn causes...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online