Lecture 11 - ATCase reaction ATCase Regulation Structure of...

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Allosteric Regulation Activity of enzymes must be regulated so that they function properly. There are several ways to regulate enzymes – Allosteric regulation is a key way One of the best well-known example of allosteric regulation is the enzyme Aspartate Transcarbamoylase or ATCase ATCase catalyzes the first step in biosynthesis of pyrimidines e.g. cytidine triphosphate (CTP). ATCase is regulated via feedback inhibition by CTP.
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ATCase Regulation
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Unformatted text preview: ATCase reaction ATCase Regulation Structure of ATCase ATCase Regulation PALA is a competitive inhibitor of ATCase ATCase Regulation Active site of ATCase ATCase Regulation The T-to-R state transition in ATCase ATCase Regulation Basis of Allosteric regulation ATCase Regulation Equilibrium of T state and R state ATCase Regulation Negative and positive regulation of ATCase ATCase Regulation Concerted (MWC) model of regulation...
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This note was uploaded on 05/05/2011 for the course BIOL 400 taught by Professor Dr.biology during the Spring '11 term at University of Tennessee.

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Lecture 11 - ATCase reaction ATCase Regulation Structure of...

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